[Kanamycin pharmacokinetics in experimental small intestine obstruction].

Pharmacokinetic studies on kanamycin administered intramuscularly in a dose of 30 mg/kg 1 hour before a surgical operation to dogs with 48-hour occlusive ileus showed a high level of the antibiotic penetration into the blood, lymph and blood of the small intestinal vascular system. About 50 per cent of the kanamycin blood concentration was determined in the peritoneal exudate and up to 20 per cent was determined in the walls of the obturated and intact small intestine, mesentery and peritoneum. The peak of the antibiotic concentration in all biosubstrates tested was recorded by the lst hour from the moment of the antibiotic administration. The method of transillumination angiotensometry used in the studies provided estimation of the blood flow adequacy and measurement of the pressure in the parietal and intramural vessels of the small intestine. Still, no information on kanamycin distribution in tissues was provided with this method.