Eriukhin I A, Poliak M S, Rukhliada N V
Vestn Khir Im I I Grek. 1981 Jul;127(7):21-6.
The experimental investigation of pharmacokinetic properties of kanamycin and cephazolin has shown the antibiotic to penetrate well into the blood, lymph, abdominal exudate. Transport of kanamycin in the wall of the strangulated intestine and its mesentery through the lymphatic system and by adsorption from the abdominal exudate is supposed to be possible. Normal concentration of the antibiotic was determined in the tissues around the strangulation zone. The concentration peak of both antibiotics was noted 1 hour after introduction in all the biosubstrates studied which may serve as an orientator for the optimal time of operation.
卡那霉素和头孢唑林药代动力学特性的实验研究表明，这两种抗生素能很好地渗透到血液、淋巴液和腹腔渗出液中。卡那霉素在绞窄性肠壁及其系膜中可能通过淋巴系统以及从腹腔渗出液中吸附进行转运。在绞窄区周围组织中测定到了抗生素的正常浓度。在所有研究的生物基质中，两种抗生素在注入后1小时均出现浓度峰值，这可为确定最佳手术时间提供参考。
