一项针对狄氏剂血药浓度升高人群的病例对照研究。
A case-control study of persons with elevated blood levels of dieldrin.
作者信息
Sandifer S H, Cupp C M, Wilkins R T, Loadholt B, Schuman S H
出版信息
Arch Environ Contam Toxicol. 1981;10(1):35-45. doi: 10.1007/BF01057573.
Twenty-seven pesticide workers with elevated blood levels of dieldrin (greater than or equal to 15 ppb) were involved in a case-control study which included history and physical examination, comprehensive neurological evaluation, laboratory tests, and psychological and psychomotor testing. No clinically important differences were found on history, physical, specialized neurological tests, or laboratory examination. The exposed group showed a statistically significant difference in five out of 58 psychological (P) and psychomotor (PM) tests--at least three would be expected by chance (p less than or equal to .05). In only one of these tests was there any significant correlation with dieldrin levels. Even though the exposed group had worse scores than the control group in 47 of 58 P--PM tests, such scores were, with a few exceptions, in the normal range of values. Elevated blood levels of dieldrin encountered in this study do not appear to have any chronic deleterious effects on health, as measured by conventional medical work-up and extensive central nervous system testing.
27名血液中狄氏剂水平升高（大于或等于15 ppb）的农药工人参与了一项病例对照研究，该研究包括病史和体格检查、全面的神经学评估、实验室检查以及心理和心理运动测试。在病史、体格、专门的神经学检查或实验室检查中未发现具有临床意义的差异。在58项心理（P）和心理运动（PM）测试中，暴露组在其中5项测试中显示出统计学上的显著差异——随机情况下预计至少会有3项（p小于或等于0.05）。在这些测试中，只有一项与狄氏剂水平有任何显著相关性。尽管在58项P-PM测试中，暴露组有47项的得分低于对照组，但除了少数例外，这些得分都在正常范围内。通过传统医学检查和广泛的中枢神经系统测试衡量，本研究中所发现的血液中狄氏剂水平升高似乎对健康没有任何慢性有害影响。
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