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[化疗与免疫刺激联合治疗汉森病的当前评估(作者译)]

[Present evaluation of hansenian treatment by association of chemotherapy and immunostimulation (author's transl)].

作者信息

Saint-Andre P, Louvet M, Giraudeau P, Discamps G, Schlecht B

出版信息

Med Trop (Mars). 1978 May-Jun;38(3):331-49.

PMID:723581
Abstract

I.--Treatment with BCG and DDS in lepromatous or borderline patients. II.--Value of BCG added to a prior and long-continued treatment with DDS or rifamipicine. III.--Value of various immunostimulants given previously to a treatment with BCG and chemotherapy. IV.--Value of lysate of Neisseria perflava as an immunostimulant associated with DDS in an initial treatment of lepromatous and borderline patients. V.--Results of a seventeen months treatment of lepromatous and borderline patients with a lysate of Neisseria perflava associated with DDS. The various therapeutic trials reported in these 5 papers demonstrate that hansenian nevritis conventionnally treated may show improvement when an immunostimulant (BCG or bacterial lysate or levamisole) is given either previously or in association with DDS or rifampicine or after such a treatment. It has still been observed that two immunostimulants given simultaneously have no good effect and that this association must be discarded.

摘要

一、用卡介苗和氨苯砜治疗瘤型或界线类患者。二、在先前长期使用氨苯砜或利福米星治疗基础上加用卡介苗的价值。三、在卡介苗和化疗治疗前给予各种免疫刺激剂的价值。四、在瘤型和界线类患者初始治疗中,将微黄奈瑟菌裂解物作为与氨苯砜联合使用的免疫刺激剂的价值。五、用微黄奈瑟菌裂解物联合氨苯砜对瘤型和界线类患者进行17个月治疗的结果。这5篇论文中报道的各种治疗试验表明,常规治疗的麻风神经炎患者,在先前给予或与氨苯砜、利福平联合使用免疫刺激剂(卡介苗、细菌裂解物或左旋咪唑)时,或在这种治疗之后,可能会有所改善。还观察到同时给予两种免疫刺激剂没有良好效果,这种联合方式必须摒弃。

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