Kitazawa Y, Horie T
Arch Ophthalmol. 1981 May;99(5):819-23. doi: 10.1001/archopht.1981.03930010819005.
Response of intraocular pressure to topical corticosteroid administration is determined genetically, and the genes that determine corticosteroid responsiveness of IOP and primary open angle glaucoma are considered closely related. To elucidate the relationship between corticosteroid responsiveness and primary open angle glaucoma, 35 patients with high corticosteroid responsiveness were followed up without therapy for at least ten years. During the follow-up period, a sustained rises in IOP greater than 21 mm Hg developed in five of 22 originally normotensive subjects. In two cases, glaucomatous field changes were demonstrated along with pressure elevation. Of 13 originally ocular hypertensives, further rise of IOP associated with glaucomatous field changes developed in seven. Results strongly indicate that pressure elevation is more likely to develop in corticosteroid-responsive individuals and the glaucomatous field defects are more likely to develop in responsive are compared with nonresponsive subjects.
眼内压对局部应用皮质类固醇的反应由基因决定，且决定眼内压皮质类固醇反应性的基因与原发性开角型青光眼密切相关。为阐明皮质类固醇反应性与原发性开角型青光眼之间的关系，对35例皮质类固醇高反应性患者未进行治疗随访至少十年。在随访期间，22例最初血压正常的受试者中有5例出现眼内压持续升高超过21毫米汞柱。在两例中，随着眼压升高出现了青光眼性视野改变。在13例最初患有高眼压症的患者中，有7例出现了与青光眼性视野改变相关的眼压进一步升高。结果强烈表明，与无反应者相比，皮质类固醇反应性个体更易出现眼压升高，且反应性个体更易出现青光眼性视野缺损。
