Stern J S, Johnson P R
Metabolism. 1977 Apr;26(4):371-80. doi: 10.1016/0026-0495(77)90104-4.
The development of spontaneous activity was studied in obese and lean Zucker rats. Rats were given access to activity wheels for 3 hr/day before weaning and for 24 hr/day after weaning. Zucker obese rats are less active than lean rats. This decreased activity occurs at weaning and follows the onset of hyperphagia and obesity. At 8 wk of age exercised lean and obese rats have less total fat and fewer adipocytes than their appropriate controls. Adipose cell size is decreased only in exercised lean rats. When rats are exercised until 8 wk of age and then confined until 6 mo of age, body weight and fat is elevated in these formerly active rats compared to control rats. Adipose cell number is permanently decreased only in formerly active lean rats. Exercise has no long-term effect in decreasing cell number in obese rats.
研究了肥胖和瘦型 Zucker 大鼠自发活动的发展情况。在断奶前，大鼠每天有 3 小时可使用活动轮，断奶后则为每天 24 小时。Zucker 肥胖大鼠的活动量比瘦大鼠少。这种活动量的减少发生在断奶时，并随着摄食过量和肥胖的出现而出现。在 8 周龄时，运动的瘦大鼠和肥胖大鼠的总脂肪量和脂肪细胞数量均比相应的对照组少。脂肪细胞大小仅在运动的瘦大鼠中减小。当大鼠运动至 8 周龄，然后限制活动直至 6 月龄时，与对照大鼠相比，这些曾经活跃的大鼠的体重和脂肪增加。脂肪细胞数量仅在曾经活跃的瘦大鼠中永久减少。运动对肥胖大鼠的细胞数量减少没有长期影响。
