Berry G
Br J Ind Med. 1981 May;38(2):130-7. doi: 10.1136/oem.38.2.130.
A mortality study has been carried out at the London, Cardiff, or Swansea Pneumoconiosis Medical Panels between 1952 and 1976 on people certified as suffering from asbestosis. The main analysis was of 665 men, 283 of whom had died. Of the deaths, 39% were from lung cancer, 9% mesothelioma, and 20% asbestosis. The observed mortality was compared with expectation based on the death rates for England and Wales. For all causes the observed number of deaths was 2.6 times expectation and for lung cancer 9.1 times expectation. After 10 years from first certification half of the men had died compared with an expectation of one in four. The excess death rates were apparent in the first year after certification and were still operating after 10 years on those who survived until then. The main factor influencing the mortality was the clinical state of the men at the time of certification, as indicated by the percentage disability awarded; the excess lung cancer rate and the mesothelioma and asbestosis rates all increased with percentage disability. Those awarded only 10% or 20% benefit were still at risk from all the three asbestos-related causes. For a man certified at age 55 it was estimated that his life expectation would be reduced by 3, 5, 8, or 12 years according to whether his rate of disablement benefit was 10%, 20%, 30% or 40% , or 50% or more respectively.
1952年至1976年间,伦敦、加的夫或斯旺西尘肺病医疗小组对被确诊患有石棉沉着病的患者进行了一项死亡率研究。主要分析对象为665名男性,其中283人已经死亡。在这些死亡病例中,39%死于肺癌,9%死于间皮瘤,20%死于石棉沉着病。将观察到的死亡率与基于英格兰和威尔士死亡率得出的预期死亡率进行了比较。所有原因导致的观察到的死亡人数是预期的2.6倍,肺癌则是预期的9.1倍。自首次确诊起10年后,一半的男性已经死亡,而预期死亡率为四分之一。超额死亡率在确诊后的第一年就很明显,并且在10年后对那些存活下来的人仍然有影响。影响死亡率的主要因素是确诊时男性的临床状况,这由评定的残疾百分比表示;肺癌超额发病率以及间皮瘤和石棉沉着病发病率均随残疾百分比的增加而上升。仅获得10%或20%福利的人仍然面临所有三种与石棉相关病因的风险。对于一名55岁确诊的男性,据估计,根据其残疾福利率分别为10%、20%、30%或40%,或50%及以上,其预期寿命将分别减少3年、5年、8年或12年。