Coutts I I, Gilson J C, Kerr I H, Parkes W R, Turner-Warwick M
Cardiothoracic Institute, Brompton Hospital, London.
Thorax. 1987 Feb;42(2):111-6. doi: 10.1136/thx.42.2.111.
One hundred and fifty five male cases of asbestosis certified by the London Pneumoconiosis Medical Panel during 1968-74 were followed up during 1978-9, 4-11 (mean 7.5) years after certification. Fifty nine patients had died, 23 (39%) from lung cancer, 6 (10%) from mesothelioma, and 11 (19%) from other respiratory causes. The number of observed deaths was 2.25 times greater than expected and 7.4 times greater than expected for lung cancer. Adenocarcinoma was the commonest histological type but other cell types were also increased. Finger clubbing (p less than 0.01) and percentage of predicted FEV1 (p less than 0.01) were of value in predicting death, but increasing profusion of small opacities greater than 1/0 (ILO/U-C international classification of radiographs of pneumoconiosis, 1971), duration of exposure to asbestos, time from first exposure to asbestos, and percentage of predicted vital capacity and transfer factor did not predict death.
1968年至1974年间，伦敦尘肺病医疗委员会确诊的155例男性石棉沉着病患者在确诊后4至11年（平均7.5年），即1978年至1979年间接受了随访。59例患者死亡，其中23例（39%）死于肺癌，6例（10%）死于间皮瘤，11例（19%）死于其他呼吸系统疾病。观察到的死亡人数比预期多2.25倍，肺癌死亡人数比预期多7.4倍。腺癌是最常见的组织学类型，但其他细胞类型也有所增加。杵状指（p<0.01）和预计第一秒用力呼气容积百分比（p<0.01）对预测死亡有价值，但小阴影密集度大于1/0（国际劳工组织/UC尘肺病X线片国际分类，1971年）、石棉暴露时长、首次接触石棉后的时间、预计肺活量百分比和转运因子百分比均不能预测死亡。
