Barendsen G W
Bull Cancer. 1981;68(2):121-6.
A review is presented of the factors which influence dose-response relationships for induction of cell reproductive death in tumours and normal tissues by radiation and chemotherapeutic agents. It is pointed out that inherent differences exist among different types of cells and that environmental conditions of cells are important. A summary is given of the various systems and responses that should be studied experimentally in order to obtain insights in the possibilities to improve cancer treatment by combined radio-chemotherapy. A few examples are discussed of the responses of a rat rhabdomyosarcoma to combined treatments with radiation and vinblastine, which illustrate the importance of cell proliferation kinetics.
本文综述了影响辐射和化疗药物在肿瘤及正常组织中诱导细胞生殖死亡的剂量反应关系的因素。指出不同类型细胞之间存在内在差异，且细胞的环境条件很重要。总结了为深入了解通过放化疗联合改善癌症治疗的可能性而应进行实验研究的各种系统和反应。讨论了大鼠横纹肌肉瘤对辐射和长春碱联合治疗的反应的几个例子，这些例子说明了细胞增殖动力学的重要性。
