硝苯地平与维拉帕米对大鼠输精管作用的比较。
A comparison of the effects of nifedipine and verapamil on rat vas deferens.
作者信息
French A M, Scott N C
出版信息
Br J Pharmacol. 1981 Jun;73(2):321-3. doi: 10.1111/j.1476-5381.1981.tb10424.x.
Abstract
Nifedipine preferentially blocks contractions of the prostatic end of the rat vas deferens to single pulse field stimulation, leaving the epididymal end largely unaffected. This action is not due entirely to antagonism of calcium influx. Verapamil unexpectedly potentiated the responses of the prostatic portion, and antagonized those of the epididymal end. The use of nifedipine may, therefore, allow investigations of adrenergic mechanisms on this tissue to be studied without the complications of non-adrenergic transmission.
摘要
硝苯地平优先阻断大鼠输精管前列腺端对单脉冲电场刺激的收缩反应，而附睾端基本不受影响。这种作用并非完全归因于对钙内流的拮抗。维拉帕米意外地增强了前列腺部的反应，并拮抗了附睾端的反应。因此，使用硝苯地平可能使对该组织肾上腺素能机制的研究得以在无非肾上腺素能传递并发症的情况下进行。
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