戊巴比妥麻醉对兔和犬血浆钾浓度影响的评估。

Evaluation of the effect of pentobarbitone anaesthesia on the plasma potassium concentration in the rabbit and the dog.

作者信息

Robson W L, Bayliss C E, Feldman R, Goldstein M B, Chen C B, Richardson R M, Stinebaugh B J, Tam S C, Halperin M L

出版信息

Can Anaesth Soc J. 1981 May;28(3):210-6. doi: 10.1007/BF03005502.

Abstract

The purpose of these studies was to determine the reasons for the hypokalaemia observed in rabbits studied in our laboratory. The rabbits consumed standard rabbit chow which is rich in potassium and remained in potassium balance. Hypokalaemia was only observed following anaesthesia. A number of additional investigations were undertaken to clarify the mechanisms involved. The hypokalaemia could not be attributed to technical factors, alkalaemia, hyperinsulinaemia or hyperaldosteronism, but seemed to be a function of anaesthesia. This effect of pentobarbitone anaesthesia was not unique to the rabbit, as similar changes also occurred in the anaesthetized dog. The findings reported in this paper have significant implications with respect to the interpretation of plasma potassium concentrations in anaesthetized subjects or animals.

摘要

这些研究的目的是确定在我们实验室所研究的兔子中观察到低钾血症的原因。兔子食用富含钾的标准兔饲料，且保持钾平衡。低钾血症仅在麻醉后观察到。进行了一系列额外的研究以阐明其中涉及的机制。低钾血症不能归因于技术因素、碱血症、高胰岛素血症或醛固酮增多症，而似乎是麻醉的一种作用。戊巴比妥麻醉的这种作用并非兔子所特有，因为在麻醉的狗身上也出现了类似的变化。本文报道的研究结果对于解释麻醉状态下的受试者或动物的血浆钾浓度具有重要意义。