Winning T J, Brock-Utne J G, Downing J W
Anesth Analg. 1977 Sep-Oct;56(5):674-7. doi: 10.1213/00000539-197709000-00014.
The antiemetic effects of droperidol, diphenidol, and placebo were compared in 210 patients subjected to minor gynecologic or urologic procedures. Atropine (0.6 mg), meperidine (1 mg/kg) body mass, and either droperidol (5 mg), diphenidol (40 mg), or 2 ml of 0.9% saline were administered IM, 1 hour before general anesthesia. Trial drugs were presented in coded ampules so that the study was conducted double-blind. Droperidol appeared superior to both diphenidol (p less than 0.01) and placebo (p less than 0.001) in the prevention of vomiting, and reduced the incidence of nausea when compared to saline (p less than 0.05). Forty-four patients experienced side effects, which occurred with similar frequency in the 3 groups studied.
在210名接受小型妇科或泌尿外科手术的患者中，比较了氟哌利多、地芬尼多和安慰剂的止吐效果。在全身麻醉前1小时，肌肉注射阿托品（0.6毫克）、哌替啶（1毫克/千克体重）以及氟哌利多（5毫克）、地芬尼多（40毫克）或2毫升0.9%生理盐水。试验药物装在编码安瓿中，因此研究采用双盲进行。在预防呕吐方面，氟哌利多似乎优于地芬尼多（p<0.01）和安慰剂（p<0.001），与生理盐水相比，氟哌利多降低了恶心的发生率（p<0.05）。44名患者出现了副作用，在所研究的3组中副作用出现的频率相似。
