Houghton A N, Flannery J, Viola M V
Cancer. 1981 Jul 15;48(2):407-10. doi: 10.1002/1097-0142(19810715)48:2<407::aid-cncr2820480231>3.0.co;2-l.
The clinical course of melanoma of the skin diagnosed during pregnancy was compared with a control population of women with melanoma that occurred during the childbearing years, as recorded by the Connecticut Tumor Registry. The survival at three and five years for the 12 patients whose melanoma developed during pregnancy was significantly worse than for 175 nonpregnant controls (five-year survival 55% for pregnant women compared with 83% for nonpregnant women, P less than 0.05). Melanoma during pregnancy tended to occur more often on the trunk, a prognostically poor site, and at more advanced stage of disease than in nonpregnant women. However, when pregnant patients were matched to random, nonpregnant case-controls by age, anatomic site of primary lesion, and stage at diagnosis, three- and five-year survivals were not different. The number of pregnant women observed among this group of women was not substantially higher than expected, when estimated from Connecticut live birth rates: 13.3 pregnancies were expected and 12 pregnant women were actually observed. However, an unknown number of pregnancies end in abortion, making more exact estimates impossible. Melanoma occurring during pregnancy usually carries a poor prognosis, but once the disease is diagnosed, the course is not worse than expected considering stage of disease and primary site.
根据康涅狄格肿瘤登记处的记录，将孕期诊断出的皮肤黑色素瘤患者的临床病程与育龄期患黑色素瘤的女性对照人群进行了比较。孕期患黑色素瘤的12名患者的3年和5年生存率明显低于175名非孕期对照者（孕期女性5年生存率为55%，非孕期女性为83%，P<0.05）。孕期黑色素瘤往往更常发生于躯干，这是一个预后较差的部位，且疾病分期比非孕期女性更晚。然而，当根据年龄、原发灶解剖部位和诊断时的分期将孕期患者与随机选取的非孕期病例对照者进行匹配后，3年和五年生存率并无差异。根据康涅狄格州的活产率估算，该组女性中观察到的孕妇数量并未显著高于预期：预期有13.3次妊娠，实际观察到12名孕妇。然而，有未知数量的妊娠以流产告终，因此无法进行更精确的估算。孕期发生的黑色素瘤通常预后较差，但一旦确诊，考虑到疾病分期和原发部位，病程并不比预期更差。
