Schwartz H S, Parker N B
Cancer Res. 1981 Jun;41(6):2343-8.
Anaerobic incubations of rat liver microsomes convert daunorubicin into at least six or seven aglycones in the presence of reduced nicotinamide adenine dinucleotide phosphate or a reduced nicotinamide adenine dinucleotide phosphate-generating system. The partial identification of some of the aglycones is based on cochromatographs of chemically synthesized derivatives by isocratic high-pressure liquid chromatography. The first major reaction is the reductive cleavage of daunorubicin to 7-deoxydaunorubicin aglycone which is converted to another product that cochromatographs with 7-deoxydaunorubicinol aglycone. The reaction follows first-order kinetics in a linear sequential pathway. Formation of 7-hydroxydaunorubicin aglycone is also identified as a product. Other reaction products are not yet identified.
在存在还原型烟酰胺腺嘌呤二核苷酸磷酸或还原型烟酰胺腺嘌呤二核苷酸磷酸生成系统的情况下，大鼠肝脏微粒体的厌氧孵育可将柔红霉素转化为至少六种或七种苷元。部分苷元的鉴定基于通过等度高压液相色谱法对化学合成衍生物的共色谱分析。第一个主要反应是柔红霉素的还原裂解生成7-脱氧柔红霉素苷元，其会转化为与7-脱氧柔红霉素醇苷元共色谱的另一种产物。该反应在一条线性顺序途径中遵循一级动力学。7-羟基柔红霉素苷元的形成也被鉴定为一种产物。其他反应产物尚未鉴定出来。
