Rantuccio F, Sinisi D, Scardigno A, Coviello C
Contact Dermatitis. 1981 Mar;7(2):94-7. doi: 10.1111/j.1600-0536.1981.tb03986.x.
A further study of the topical effects of certain pharmaceutical and cosmetic bases on rabbit skin is reported. Cetyl alcohol, myristic acid, castor oil and sorbitol were applied in fixed doses daily for 30 days and their irritant activity was assessed. The macroscopic and microscopic changes were on the whole minimal. Castor oil alone produced some macroscopic alterations in the form of slight erythema and edema, and microscopic changes consisting of acanthosis, disorganization of the basal layer and slight infiltration of the dermis.
本文报道了对某些药物和化妆品基质对兔皮肤局部作用的进一步研究。每天以固定剂量涂抹十六醇、肉豆蔻酸、蓖麻油和山梨醇，持续30天，并评估其刺激活性。大体和微观变化总体上最小。仅蓖麻油产生了一些大体改变，表现为轻微红斑和水肿，微观变化包括棘层肥厚、基底层紊乱和真皮轻度浸润。
