Rantuccio F, Scardigno A, Conte A, Sinisi D, Coviello C
Contact Dermatitis. 1979 Dec;5(6):392-7. doi: 10.1111/j.1600-0536.1979.tb04912.x.
A staged histological study of skin changes induced in rabbits by daily application of five bases used for topical medicaments and cosmetics, namely glycols, petrolatum, Modulan, Acetulan and Amerchol L 101, over periods of 100 days, is reported. Sections obtained every 10 days were examined for changes in the epithelium, in the character of the dermal infiltrate and in the superficial collagen fibers. Glycols showed no particular effects on the skin; petrolatum produced acanthosis and vacuolization in the epidermis, and mononuclear cell infiltration of the dermis but evident collagen changes. Lanolin derivatives produced acanthosis and vacuolization of the epidermis, with lymphomonouclear infiltration of the dermis and with dissociation of collagen; examination around the 30th day showed a tendency to basal layer disorganization by the infiltrate.
报道了一项分阶段的组织学研究，该研究观察了家兔皮肤在100天内每日涂抹用于局部用药和化妆品的五种基质（即二醇、凡士林、莫杜兰、乙酰化羊毛脂和美国胆固醇L101）所引起的变化。每隔10天获取切片，检查上皮细胞、真皮浸润特征和浅表胶原纤维的变化。二醇对皮肤无特殊影响；凡士林导致表皮棘皮症和空泡形成，真皮单核细胞浸润，但胶原变化明显。羊毛脂衍生物导致表皮棘皮症和空泡形成，真皮有淋巴细胞单核细胞浸润以及胶原解离；在第30天左右检查发现，浸润有使基底层紊乱的趋势。
