Rantuccio F, Sinisi D, Coviello C, Conte A, Scardigno A
Contact Dermatitis. 1984 Apr;10(4):212-9. doi: 10.1111/j.1600-0536.1984.tb00102.x.
An experimental study is reported of the irritant potential of oil of purcellin , isopropyl palmitate, nonyl phenol, Modulan , Amerchol and Acetulan when massaged in fixed amounts into the rabbit's skin daily for 30 days. Skin biopsies provided data on the number of epithelial cell layers, cell counts of the superficial dermis, and the fibre and basement membrane changes. All the test compounds induced changes in the form of increased number of epithelial cell layers and of the papillary dermis cell count, more marked for Acetulan or Amerchol . The difficulties in the evaluation of the results and their applications to human pathology are discussed.
本文报道了一项实验研究，该研究观察了每日将固定量的珀塞尔油、棕榈酸异丙酯、壬基酚、莫杜兰、阿美科和乙酰基乙醇按摩于兔皮肤30天的刺激潜力。皮肤活检提供了有关上皮细胞层数、浅表真皮细胞计数以及纤维和基底膜变化的数据。所有测试化合物均引起上皮细胞层数和乳头真皮细胞计数增加形式的变化，乙酰基乙醇或阿美科的变化更为明显。文中还讨论了评估结果的困难及其在人类病理学中的应用。
