Siklósi C, Simon N, Kószó F
Derm Beruf Umwelt. 1981;29(2):40-2.
In answering the question as to what role possible metabolites of hexachlorobenzene play in the procreation of toxic hexachlorobenzene porphyria in rats, both pure hexachlorobenzene and different mixtures were fed to them. In each case 20% of the hexachlorobenzene was replaced by pentachlorophenol, 1,2,4,5-tetrachlorobenzene, 1,2,3,4-tetrachlorobenzene, 1,2,3,5-tetrachlorobenzene, 2,3,4,5-tetrachlorophenol, 2,3,5,6-tetrachlorophenol, 2,3,4,6-tetrachlorophenol or chloranil. The determination of porphyrins at different intervals once the feeding had started did not give rise to an increase in the porphyria in any of these substances--which are seen as metabolites of hexachlorobenzene. Instead there was a distinct decrease in individual cases. From this the conclusion is drawn that none of the tested substances is the metabolite of hexachlorobenzene, which is in fact responsible for the hexachlorobenzene porphyria.
在回答关于六氯苯的可能代谢产物在大鼠中毒性六氯苯卟啉症的发生过程中起何种作用的问题时，给大鼠喂食了纯六氯苯和不同的混合物。在每种情况下，六氯苯的20%被五氯酚、1,2,4,5 - 四氯苯、1,2,3,4 - 四氯苯、1,2,3,5 - 四氯苯、2,3,4,5 - 四氯酚、2,3,5,6 - 四氯酚、2,3,4,6 - 四氯酚或四氯苯醌所取代。在开始喂食后的不同时间段对卟啉进行测定，结果显示这些被视为六氯苯代谢产物的物质均未导致卟啉症增加。相反，个别情况下出现了明显下降。由此得出结论，所测试的物质均不是六氯苯的代谢产物，而实际上正是这种代谢产物导致了六氯苯卟啉症。
