Azadeh B, Parai S K
Histopathology. 1980 Nov;4(6):653-9. doi: 10.1111/j.1365-2559.1980.tb02961.x.
The occurrence of argentaffin cells, intestinal metaplasia, and antral metaplasia has been studied in 20 gall bladders with carcinomas, in a papilloma, and in 20 specimens of cholelithiasis. Argentaffin cells were present in six carcinomas, but in only one specimen were they present in large numbers. Only one adenocarcinoma contained occasional argyrophil cells and no argentaffin or argyrophil cells were seen in the papilloma. Five of the 20 specimens of cholelithiasis contained occasional argentaffin cells. Intestinal and antral metaplasia were found in four carcinomas, in the papilloma, and in seven of the 20 specimens of cholelithiasis. It is suggested that metaplastic changes may play a role in the pathogenesis of carcinoma of the gall bladder.
对20例胆囊癌、1例乳头状瘤及20例胆石症标本进行了嗜银细胞、肠化生及胃窦化生的研究。嗜银细胞见于6例胆囊癌，但仅1例标本中数量较多。仅1例腺癌偶见亲银细胞，乳头状瘤中未见嗜银或亲银细胞。20例胆石症标本中有5例偶见嗜银细胞。4例胆囊癌、乳头状瘤及20例胆石症标本中的7例发现有肠化生及胃窦化生。提示化生改变可能在胆囊癌的发病机制中起作用。
