Powell P C, Rennie M, Ross L J, Mustill B M
Int J Cancer. 1980 Nov 15;26(5):681-7. doi: 10.1002/ijc.2910260522.
Immunization with inactivated viral antigens protected chickens against Marek's disease. Non-immunized chickens could be protected by injections of spleen cells but not of serum from immunized, histocompatible donors. Chickens rendered agamma-globulinaemic by bursectomy and irradiation could also be immunized against Marek's disease by inoculation with viral antigens, but spleen cells from these immunized, bursectomized and irradiated donors did not confer protection on the recipients into which they were injected. It was concluded that, although in the bursectomized, immunized donors cell-mediated immunity alone was able to provide a fair degree of protection against Marek's disease, the protection afforded against the disease by spleen-cell transfer was at least partly attributable to the transfer of antibody-producing cells, and that humoral immunity, while not being an absolute requirement for resistance, is normally an important component of the resistance mechanism.
用灭活病毒抗原进行免疫可保护鸡免受马立克氏病的侵害。未免疫的鸡可通过注射脾脏细胞得到保护，但不能通过注射来自免疫的、组织相容性供体的血清得到保护。通过法氏囊切除和照射使鸡产生无丙种球蛋白血症后，也可通过接种病毒抗原使其对马立克氏病产生免疫，但来自这些经免疫、法氏囊切除和照射的供体的脾脏细胞不能对接受注射的受体提供保护。得出的结论是，虽然在经法氏囊切除、免疫的供体中，仅细胞介导的免疫就能提供一定程度的针对马立克氏病的保护，但脾脏细胞转移所提供的针对该病的保护至少部分归因于抗体产生细胞的转移，而且体液免疫虽然不是抵抗该病的绝对必要条件，但通常是抵抗机制的重要组成部分。
