Sturrock R R
Neuropathol Appl Neurobiol. 1978 Sep-Oct;4(5):307-22. doi: 10.1111/j.1365-2990.1978.tb01345.x.
Intraventricular macrophages are first seen attached to the presumptive choroid plexus in the 11 days postconception mouse. By 12 day postconception supraependymal macrophages are present as well as a few macrophages lying apparently free within the ventricles. The number of epiplexus, supraependymal and free macrophages increases rapidly and reaches a peak at 17 days postconception, then fall rapidly until 4 days post natum. A second increase in epiplexus and supraependymal cells occurs at 8 days post natum followed by another decrease up to 15 days post natum. Microglia were first observed in the brain at 13 days postconception and at 17 days postconception a microglial cell was observed apparently entering the ependyma from the ventricle. It is suggested that the large decrease in intraventricular macrophages after 17 days postconception is due to many of these cells migrating into the brain to give rise to microglia. The intraventricular macrophages themselves probably arise from within the choroid plexus, either from stromal cells or from blood-borne macrophages.
在受孕后11天的小鼠中，首次观察到脑室内巨噬细胞附着在假定的脉络丛上。到受孕后12天，室管膜上巨噬细胞出现，同时也有一些巨噬细胞明显游离于脑室内。脉络丛、室管膜上和游离巨噬细胞的数量迅速增加，并在受孕后17天达到峰值，然后迅速下降，直到出生后4天。脉络丛和室管膜上细胞在出生后8天再次增加，随后在出生后15天再次减少。小胶质细胞在受孕后13天首次在脑中被观察到，在受孕后17天，观察到一个小胶质细胞显然从脑室进入室管膜。有人认为，受孕后17天后脑室内巨噬细胞的大量减少是由于这些细胞中的许多迁移到脑中产生了小胶质细胞。脑室内巨噬细胞本身可能起源于脉络丛内，要么来自基质细胞，要么来自血源性巨噬细胞。
