Ahlberg J, Curstedt T, Einarsson K, Sjövall J
J Lipid Res. 1981 Mar;22(3):404-9.
Molecular species of phosphatidylcholines were analyzed in hepatic and gallbladder bile obtained from six subjects with adenomyoma of the gallbladder (gallstone-free controls) and 27 gallstone patients undergoing cholecystectomy. Seven of the gallstone patients had been treated with cholic acid and seven with chenodeoxycholic acid for at least 8 weeks before operation. The two predominant species were 1-palmitoyl-2-oleoyl- and 1-palmitoyl-2-linoleoyl-sn-glycerophosphocholines which together accounted for 75-80% of the total amount of phosphatidylcholines. Minor species were 1-palmitoyl-2-palmitoleoyl-, 1-stearoyl-2-linoleoyl-, 1-oleoyl-2-linoleoyl-, and 1-palmitoyl-2-arachidonoyl-sn-glycerophosphocholines. Gallstone patients had a higher portion of the 1-palmitoyl-2-oleoyl species and a concomitant lower proportion of the 1-palmitoyl-2-linoleoyl species than gallstone-free subjects. The ratio between the two species was about 0.7 and 0.4, respectively, in the hepatic bile of the two groups of patients. Treatment with bile acids was associated with a normalization of the pattern of phosphatidylcholines.
对6名胆囊腺肌瘤患者（无胆结石对照）以及27名接受胆囊切除术的胆结石患者的肝脏胆汁和胆囊胆汁中的磷脂酰胆碱分子种类进行了分析。其中7名胆结石患者在手术前至少8周接受了胆酸治疗，7名接受了鹅去氧胆酸治疗。两种主要的磷脂酰胆碱种类为1-棕榈酰-2-油酰基-和1-棕榈酰-2-亚油酰基-sn-甘油磷酸胆碱，它们合起来占磷脂酰胆碱总量的75 - 80%。次要种类为1-棕榈酰-2-棕榈油酰基-、1-硬脂酰-2-亚油酰基-、1-油酰基-2-亚油酰基-和1-棕榈酰-2-花生四烯酰基-sn-甘油磷酸胆碱。与无胆结石患者相比，胆结石患者的1-棕榈酰-2-油酰基种类比例更高，而1-棕榈酰-2-亚油酰基种类的比例则更低。两组患者肝脏胆汁中这两种磷脂酰胆碱种类的比例分别约为0.7和0.4。胆汁酸治疗使磷脂酰胆碱模式恢复正常。
