Thistle J L, Hofmann A F, Yu P Y, Ott B
Am J Dig Dis. 1977 Jan;22(1):1-6. doi: 10.1007/BF01077389.
In a dose-response study, a formulation of chenodeoxycholic acid (chenic acid) with complete bioavailability was fed at doses of 0, 250, 500, 750 mg for randomized 6-week periods to 13 patients with radiolucent gallstones. The proportion of chenic acid in biliary bile acids increased in direct relation to dose. Lithocholic acid also increased, but ursodeoxycholic acid showed no significant change. Bile saturation decreased with increasing dose, but response was variable and achieved significance only at 750 mg/day. Cholesterol saturation was negatively correlated with the proportion of chenic acid in biliary bile acids: When biliary bile acids contained greater than 70% chenic acid (and ursodeoxycholic acid), bile became unsaturated, on the average. The data suggest that a dose of at least 10-15 mg/kg may be necessary to obtain desaturation in many gallstone patients.
在一项剂量反应研究中，将具有完全生物利用度的鹅去氧胆酸（鹅胆酸）制剂以0、250、500、750毫克的剂量，随机给予13名患有透X线胆结石的患者，为期6周。胆汁中鹅胆酸的比例与剂量呈直接关系增加。石胆酸也增加，但熊去氧胆酸无显著变化。胆汁饱和度随剂量增加而降低，但反应存在差异，仅在750毫克/天时达到显著水平。胆固醇饱和度与胆汁中鹅胆酸的比例呈负相关：当胆汁中鹅胆酸（和熊去氧胆酸）含量大于70%时，胆汁平均变为不饱和。数据表明，在许多胆结石患者中，可能需要至少10 - 15毫克/千克的剂量才能实现去饱和。
