Naeye R L
Obstet Gynecol. 1978 Nov;52(5):521-5.
The pathogenesis of placenta previa was analyzed in a large prospective study that included more than 1000 medical, demographic, hereditary, and postmortem variables. It caused 73 perinatal deaths per 100,000 births. The frequency of the deaths increased with short maternal stature, increasing parity, prior preterm deliveries, and prior perinatal deaths. More male infants died than females. Placentas showed diffuse hyperplastic enlargement of terminal villi, marginal decidual necrosis, and marginal thrombi. These abnormalities were likely related to blood loss and abruption. Both the infants who died and those who survived had a pattern of fetal growth retardation characteristic of undernutrition. Long-term physical growth and psychomotor development were normal in the surviving infants except for a small excess of neurologic abnormalities.
在一项大型前瞻性研究中分析了前置胎盘的发病机制，该研究纳入了1000多个医学、人口统计学、遗传和尸检变量。每10万例分娩中，前置胎盘导致73例围产期死亡。死亡频率随着母亲身材矮小、产次增加、既往早产和既往围产期死亡而增加。男性婴儿死亡多于女性。胎盘显示终末绒毛弥漫性增生性肿大、边缘蜕膜坏死和边缘血栓形成。这些异常可能与失血和胎盘早剥有关。死亡和存活的婴儿均有营养不良特征性的胎儿生长受限模式。除了神经异常略多外，存活婴儿的长期身体生长和精神运动发育正常。
