Serra A, Camps J, Morlans M, Olmos A, Carrera A, Soriano B, Rodríguez J A, Pelegrí A, Bartolomé J, Piera L
Med Clin (Barc). 1981 May 10;76(10):439-43.
Anemia is one of the complications of terminal chronic renal failure that may worsen with periodical hemodialysis because of residual blood losses in the dialyzers that may be significant if clotting occurs within the circulation system. The potential iron deficiency component of the anemia has been studied in 86 patients submitted to periodic hemodialysis by measurement of hemoglobin, serum iron, transferrin saturation, total iron binding capacity, and ferritin. The following correlations were investigated: degree of anemia and type of renal disease, months on hemodialysis and hemoglobin, months on hemodialysis and serum ferritin, and liters of blood transfused and serum ferritin. Statistically significant correlations were found between months on hemodialysis and hemoglobin, and between liters of blood transfused and serum ferritin. From the correlation between serum iron and ferritin the patients could be classified in three groups: 1, with either normal or low serum iron and ferritin, candidates to iron therapy; 2, with elevated serum iron and ferritin, needing no iron treatment; and 3, with unequal changes of serum iron and ferritin, in whom iron kinetic studies are indicated in order to discover the patents that may benefit from iron therapy.
贫血是终末期慢性肾衰竭的并发症之一，由于透析器中存在残余失血，如果循环系统内发生凝血，残余失血可能相当可观，因此定期血液透析可能会使贫血加重。通过测量血红蛋白、血清铁、转铁蛋白饱和度、总铁结合力和铁蛋白，对86例接受定期血液透析的患者贫血潜在的缺铁成分进行了研究。研究了以下相关性：贫血程度与肾脏疾病类型、血液透析月数与血红蛋白、血液透析月数与血清铁蛋白，以及输血升数与血清铁蛋白。在血液透析月数与血红蛋白之间，以及输血升数与血清铁蛋白之间发现了具有统计学意义的相关性。根据血清铁和铁蛋白之间的相关性，患者可分为三组：1. 血清铁和铁蛋白正常或偏低，适合进行铁治疗；2. 血清铁和铁蛋白升高，无需铁治疗；3. 血清铁和铁蛋白变化不一致，需要进行铁动力学研究以发现可能从铁治疗中受益的患者。
