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大风子油酸:整合入分枝杆菌的复合脂质中。

Chaulmoogric acid: assimilation into the complex lipids of mycobacteria.

作者信息

Cabot M C, Goucher C R

出版信息

Lipids. 1981 Feb;16(2):146-8. doi: 10.1007/BF02535690.

DOI:10.1007/BF02535690
PMID:7242271
Abstract

Lipid analysis of Mycobacterium vaccae, grown in the presence of chaulmoogric acid, demonstrates that this cyclopentenyl fatty acid is taken up by the organism and incorporated into cellular phospholipids and triacylglycerols. As cell growth is retarded by the addition of chaulmoogric acid to the growth medium, it is possible that the antimicrobial properties of this compound results from a perturbation of membrane processes.

摘要

在大风子油酸存在的情况下生长的母牛分枝杆菌的脂质分析表明,这种环戊烯基脂肪酸被该生物体摄取并掺入细胞磷脂和三酰甘油中。由于向生长培养基中添加大风子油酸会抑制细胞生长,因此这种化合物的抗菌特性可能是由膜过程的扰动导致的。

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The activity of chaulmoogra acids against Mycobacterium leprae.大风子油酸对麻风分枝杆菌的活性。
Am Rev Respir Dis. 1975 May;111(5):703-5. doi: 10.1164/arrd.1975.111.5.703.