Oster P, Schlierf G, Heuck C C, Hahn S, Szymanski H, Schellenberg B
Lipids. 1981 Feb;16(2):93-7. doi: 10.1007/BF02535680.
The acute and subacute effects of different diets on serum high density lipoprotein (HDL) cholesterol concentration and/or HDL composition are described. In obese normolipemic, hypercholesterolemic (type II) and hypertriglyceridemic (type IV) patients, low HDL cholesterol values remained low during total starvation for 2 weeks. Prudent diets in patients with type II and IV hyperlipoproteinemia had no significant effects on HDL cholesterol within 3 weeks, whereas in normal individuals, a high carbohydrate diet given for 10 days caused significant decreases in HDL cholesterol with concomitant increases in HDL triglycerides as compared to a high-fat diet. The HDL triglyceride fatty acid composition changed in healthy volunteers during the day, depending on the type of ingested fat. The data demonstrate the possibility of acute manipulations of HDL in normal patients and the difficulties of normalizing low HDL cholesterol levels in patients by dietary means. Additional information on the function of HDL is desirable before the therapeutic manipulation of HDL cholesterol or other constituents of HDL can be evaluated regarding their effectiveness in the prevention of ischemic vascular disease.
本文描述了不同饮食对血清高密度脂蛋白（HDL）胆固醇浓度和/或HDL组成的急性和亚急性影响。在肥胖的血脂正常者、高胆固醇血症（II型）和高甘油三酯血症（IV型）患者中，为期2周的完全饥饿期间，低HDL胆固醇值持续保持较低水平。II型和IV型高脂蛋白血症患者采用谨慎饮食，3周内对HDL胆固醇无显著影响，而在正常个体中，与高脂饮食相比，给予10天的高碳水化合物饮食会导致HDL胆固醇显著降低，同时HDL甘油三酯增加。健康志愿者的HDL甘油三酯脂肪酸组成在一天中会发生变化，这取决于摄入脂肪的类型。这些数据表明在正常患者中急性调控HDL的可能性，以及通过饮食手段使患者低HDL胆固醇水平正常化的困难。在评估HDL胆固醇或HDL其他成分在预防缺血性血管疾病中的有效性之前，对HDL功能的更多信息是必要的。
