Kangwanpong D, Arseculeratne S N, Sirisinha S
Mutat Res. 1981 May;89(1):63-8. doi: 10.1016/0165-1218(81)90131-2.
Palmyrah (Borassus flabellifer) flour is consumed by humans in some Asian and African countries. In view of its toxic and carcinogenic effects, including the induction of malignant lymphomas in rats, we examined the mutagenic effects of aqueous extracts of the flour on human blood lymphocytes in vitro. The extracts were clastogenic, mainly to group A chromosomes, producing chromatid and chromosome gaps, and chromatid and chromosome breaks with some formation of large and small acentric fragments. Dicentric chromosomes and chromatid interchanges were rare. No ring chromosome was detected. These effects were dose-dependent and were consistently produced by crude extracts of different batches of flour, but were less frequent than the clastogenic effects of mitomycin C which was used as a positive control. No mitogenic effect of the extracts alone was observed.
在一些亚洲和非洲国家，人们食用扇叶树头榈（Borassus flabellifer）面粉。鉴于其毒性和致癌作用，包括在大鼠中诱发恶性淋巴瘤，我们在体外研究了该面粉水提取物对人血淋巴细胞的诱变作用。提取物具有断裂剂作用，主要作用于A组染色体，产生染色单体和染色体间隙、染色单体和染色体断裂，并形成一些大小不等的无着丝粒片段。双着丝粒染色体和染色单体互换很少见。未检测到环状染色体。这些效应呈剂量依赖性，不同批次面粉的粗提物均能持续产生这些效应，但比作为阳性对照的丝裂霉素C的断裂剂效应频率低。单独提取物未观察到促有丝分裂作用。
