Aslam M, Fatima N, Rahman Q
Industrial Toxicology Research Centre, Lucknow, India.
Mutat Res. 1993 Jun;300(1):45-8. doi: 10.1016/0165-1218(93)90138-4.
Calcium silicate has been considered as a possible replacement for asbestos due to its heat and fire resistance. We describe the cytotoxic and genotoxic potential of calcium silicate using peripheral human blood lymphocytes. Calcium silicates at concentrations of 10 and 100 micrograms/ml significantly increased the frequencies of chromosomal aberrations (CAs) and sister-chromatid exchanges (SCEs). The increases in CAs and SCEs were dose-dependent, though not linearly. A significant decrease in the proliferation rate index was observed with increased dose of calcium silicates. The induction of chromatid-type aberrations indicates that the clastogenic activity of calcium silicate is S-phase-dependent.
由于硅酸钙具有耐热和耐火性，它被认为是石棉的一种可能替代品。我们使用人外周血淋巴细胞来描述硅酸钙的细胞毒性和遗传毒性潜力。浓度为10微克/毫升和100微克/毫升的硅酸钙显著增加了染色体畸变（CAs）和姐妹染色单体交换（SCEs）的频率。CAs和SCEs的增加呈剂量依赖性，但并非线性关系。随着硅酸钙剂量的增加，增殖率指数显著下降。染色单体型畸变的诱导表明硅酸钙的致断裂活性是S期依赖性的。
