Skinner S J, Campos G A, Liggins G C
Obstet Gynecol. 1981 Apr;57(4):487-9.
The collagen content of amniotic membranes was measured in samples obtained at delivery from patients with and without premature rupture of the membranes (PROM). In samples from patients with PROM the collagen content (343 microgram/mg) was significantly lower than in samples from patients without PROM (373 microgram/mg) (P less than .005). The collagen content decreased between 32 and 40 weeks' gestation from 446 to 362 microgram/mg (r = .588; P less than .001) in patients without PROM and from 393 to 332 microgram/mg (r = -.362; P less than .05) in patients with PROM. The latent period between membrane rupture and delivery was not associated with a decrease in collagen content. The changes in amnion collagen during gestation and the differences observed with PROM suggest that weakening of the amnion in preparation for rupture may be determined partly by factors controlling the synthesis and degradation of collagen.
对有胎膜早破（PROM）和无胎膜早破的产妇分娩时获取的羊膜样本进行胶原含量测定。有胎膜早破产妇的样本中胶原含量（343微克/毫克）显著低于无胎膜早破产妇的样本（373微克/毫克）（P＜0.005）。无胎膜早破的产妇在妊娠32至40周期间，胶原含量从446微克/毫克降至362微克/毫克（r = 0.588；P＜0.001），而有胎膜早破的产妇则从393微克/毫克降至332微克/毫克（r = -0.362；P＜0.05）。胎膜破裂至分娩的潜伏期与胶原含量降低无关。妊娠期间羊膜胶原的变化以及胎膜早破时观察到的差异表明，羊膜为破裂做准备时的弱化可能部分由控制胶原合成和降解的因素决定。
