Vadillo-Ortega F, González-Avila G, Karchmer S, Cruz N M, Ayala-Ruiz A, Lama M S
División de Investigación Biomédica, Facultad de Ciencias, Universidad Nacional Autónoma de México.
Obstet Gynecol. 1990 Jan;75(1):84-8.
Collagen content, acid-soluble collagen, degradation activity, and collagen biosynthesis were measured in 22 normal and 20 prematurely ruptured membranes from pregnancies near term (37 weeks or more). Although no significant differences were found in the collagen content, a clear correlation was found between this value and the interval from premature rupture to delivery. Collagenolytic activity and collagen solubility were higher and collagen synthesis was lower in amniotic membranes that ruptured prematurely. These studies suggest that premature rupture of membranes is associated with extensive changes in collagen metabolism.
在22例足月（37周及以上）妊娠的正常胎膜和20例胎膜早破的胎膜中，测量了胶原蛋白含量、酸溶性胶原蛋白、降解活性和胶原蛋白生物合成。尽管在胶原蛋白含量上未发现显著差异，但该值与胎膜早破至分娩的间隔时间之间存在明显的相关性。在胎膜早破的羊膜中，胶原olytic活性和胶原蛋白溶解度较高，而胶原蛋白合成较低。这些研究表明，胎膜早破与胶原蛋白代谢的广泛变化有关。
