Wilkinson E J, Friedrich E G, Fu Y S
Obstet Gynecol. 1981 Jul;58(1):69-74.
A detailed histologic and DNA-microspectrophotometric study is presented of 31 lesions selected from 12 of 65 patients with vulvar carcinoma in situ whom the authors have seen. In 6 patients the lesions were multicentric and in 6 they were confluent. The purpose of the study was to determine whether or not there was a measurable biologic difference between these 2 distinctly different clinical lesions that would justify separating them into different categories. A hypothesis as to the clonal evolution of multicentric and confluent vulvar carcinoma is presented based on the authors' findings.
本文对从作者所诊治的65例原位外阴癌患者中的12例选取的31个病变进行了详细的组织学和DNA显微分光光度研究。6例患者的病变为多中心性，6例为融合性。本研究的目的是确定这两种明显不同的临床病变之间是否存在可测量的生物学差异，从而证明将它们分为不同类别是合理的。基于作者的研究结果，提出了关于多中心性和融合性外阴癌克隆进化的假说。
