Friedrich E G, Wilkinson E J, Fu Y S
Am J Obstet Gynecol. 1980 Apr 1;136(7):830-43. doi: 10.1016/0002-9378(80)91039-x.
The epidemiologic data, clinical features, associated diseases, and histologic characteristics present in 50 cases of carcinoma in situ of the vulva are analyzed. A comparison of follow-up results obtained with various treatment methods is presented. With primary surgery the recurrence rate is dependent on the presence or absence of tumor at the surgical margins. Deoxyribonucleic acid patterns, determined by microspectrophotometry, were aneuploid in 92% of the cases studied. Five patients (10%) with aneuploid lesions, observed without therapy, experienced spontaneous regression of tumor and replacement of abnormal areas by euploid epithelium.
分析了50例外阴原位癌的流行病学数据、临床特征、相关疾病及组织学特征。并对采用不同治疗方法所获得的随访结果进行了比较。采用一期手术时，复发率取决于手术切缘有无肿瘤。通过显微分光光度法测定的脱氧核糖核酸模式显示，在所研究的病例中，92%为非整倍体。5例（10%）非整倍体病变患者未经治疗，肿瘤出现自发消退，异常区域被整倍体上皮取代。
