DNA一级结构中的周期性由编码蛋白质的二级结构决定。
Periodicity in DNA primary structure is defined by secondary structure of the coded protein.
作者信息
Zhurkin V B
出版信息
Nucleic Acids Res. 1981 Apr 24;9(8):1963-71. doi: 10.1093/nar/9.8.1963.
Abstract
A 10.5-base periodicity found earlier is inherent in both eu- and prokaryotic coding nucleotide sequences. In the case of noncoding eukaryotic sequences no periodicity is found, so the 10.5-base oscillation seemingly does not correlate with the nucleosomal organization of DNA. It is shown that the DNA fragments, coding the alpha-helical protein segments, manifest the pronounced 10.5-base periodicity, while those regions of DNA which code the beta-structure have a 6-base oscillation. The repeating pattern of nucleotide sequences can be used for comparison of the DNA segments with low degree of homology.
摘要
先前发现的10.5碱基周期存在于真核和原核编码核苷酸序列中。在非编码真核序列的情况下未发现周期性，因此10.5碱基振荡似乎与DNA的核小体组织无关。结果表明，编码α螺旋蛋白片段的DNA片段表现出明显的10.5碱基周期，而编码β结构的DNA区域则有6碱基振荡。核苷酸序列的重复模式可用于比较低同源性的DNA片段。
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