染色质DNA的螺距反映在其核苷酸序列中。
The pitch of chromatin DNA is reflected in its nucleotide sequence.
作者信息
Trifonov E N, Sussman J L
出版信息
Proc Natl Acad Sci U S A. 1980 Jul;77(7):3816-20. doi: 10.1073/pnas.77.7.3816.
Abstract
A correlation analysis of chromatin DNA nucleotide sequences reveals the clear tendency of some of the dinucleotides to be repeated along the sequences with periods of 3 and about 10.5 bases. This latter period, which is equal within experimental error to recent estimates of the pitch of the DNA double helix [Wang, J. (1979) Proc. Natl. Acad. Sci. USA 76, 200-203; Trifonov, E. & Bettecken, T. (1979) Biochemistry 18, 454-456] is interpreted as a reflection of the deformational anisotropy of the DNA molecule that facilitates its smooth folding in chromatin.
摘要
染色质DNA核苷酸序列的相关性分析显示，某些二核苷酸沿着序列以3个碱基和大约10.5个碱基的周期重复出现的明显趋势。后一个周期在实验误差范围内与最近对DNA双螺旋螺距的估计值相等[王，J.（1979年）《美国国家科学院院刊》76, 200 - 203；特里福诺夫，E. & 贝泰肯，T.（1979年）《生物化学》18, 454 - 456]，这被解释为DNA分子变形各向异性的一种反映，这种各向异性有助于其在染色质中顺利折叠。
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