Lipton J M, Glyn J R
Peptides. 1980 Spring;1(1):15-8. doi: 10.1016/0196-9781(80)90029-7.
Sixteen peptides were injected intracerebroventricularly to test their effects on rectal temperature of rabbits in a thermoneutral environment. In initial tests 5 micrograms alpha-MSH, ACTH(1--24), oxytocin, vasopressin and glucagon altered body temperature while ACTH(1--10), cholecystokinin, contraceptive tetrapeptide, gastrin, insulin, interferon, leupeptin, LHRH, panhibin (somatostatin), and proctolin did not. Bombesin also altered body temperature but in no consistent direction. In further tests on the effective peptides 1.25--5.0 micrograms alpha-MSH and ACTH(1--24) produced dose-related decreases in rectal temperature as great as 1.0 degrees C. The same doses of oxytocin and glucagon produced small, prolonged hyperthermias which did not exceed 0.4 degrees C. Vasopressin caused rapid development of small increases in rectal temperature; temperature returned to normal in 2--3 hr. The results suggest that five of the peptides tested may have roles in central mediation of normal body temperature, hypothermia, hyperthermia and fever.
将16种肽经脑室内注射，以测试它们在热中性环境中对家兔直肠温度的影响。在初始试验中，5微克的α-促黑素、促肾上腺皮质激素（1-24）、催产素、血管加压素和胰高血糖素可改变体温，而促肾上腺皮质激素（1-10）、胆囊收缩素、避孕四肽、胃泌素、胰岛素、干扰素、亮抑蛋白酶肽、促黄体激素释放激素、泛抑制素（生长抑素）和原肌球蛋白则无此作用。蛙皮素也可改变体温，但无一致的变化方向。在对有效肽的进一步试验中，1.25-5.0微克的α-促黑素和促肾上腺皮质激素（1-24）可使直肠温度呈剂量相关下降，降幅高达1.0℃。相同剂量的催产素和胰高血糖素可引起小幅度、持续时间较长的体温升高，不超过0.4℃。血管加压素可使直肠温度迅速小幅升高；2-3小时后体温恢复正常。结果表明，所测试的5种肽可能在正常体温、体温过低、体温过高及发热的中枢调节中起作用。
