Kedryna T, Gumińska M, Eckstein M
Pol J Pharmacol Pharm. 1980 Nov-Dec;32(6):883-8.
Among the optical isomers of N, N'-dimethyl-N, N'-bis[1-(3', 4', 5-trimethoxybenzoyloxy)-butyl-2]-ethylenediamine dihydrochloride only the isomer with the (2S, 2'S) configuration (Craviten) in a concentration of 0.2 microgram/ml inhibits the ADP-induced aggregation of human platelets. The (2R, 2'R) isomer and quinidine exert a similar effect but only in a concentration ten times higher. Procaine amide (2 micrograms/ml) has an opposite effect, stimulating human platelet aggregation.
在N，N'-二甲基-N，N'-双[1-（3'，4'，5-三甲氧基苯甲酰氧基）-丁基-2]-乙二胺二盐酸盐的旋光异构体中，只有浓度为0.2微克/毫升的(2S, 2'S)构型异构体（克立凡亭）能抑制二磷酸腺苷诱导的人血小板聚集。(2R, 2'R)异构体和奎尼丁也有类似作用，但浓度要高10倍。普鲁卡因酰胺（2微克/毫升）则有相反作用，会刺激人血小板聚集。
