（2S，2'S）-N，N'-二甲基-N，N'-双[1-（3'，4'，5'-三甲氧基苯甲酰氧基）-丁基-2]乙二胺二盐酸盐（M-71）无致畸性和胚胎毒性。

Lack of teratogenic and embryotoxic properties of (2S, 2'S) N,N'-dimethyl-N,N'-bis [1-(3', 4', 5'-trimethoxybenzoyloxy)-butyl-2] ethylenediamine dihydrochloride (M-71).

作者信息

Dłuzniewski A, Gastoł-Lewińska L, Buczyńska B, Gródecka A, Kwiatek H

出版信息

Pol J Pharmacol Pharm. 1980 Nov-Dec;32(6):893-908.

Abstract

(2S,2'S) N,N'-dimethyl-N, N'-bis[1-(3', 4', 5'-trimethylbenzoyloxy-butyl-2] ethylenediamine dihydrochloride (M-781, Craviten Polfa) was examined for teratogenic and embryotoxic activities in rats, golden hamsters and rabbits. Doses ranging from 3 to 450 mg/kg po i.e. 1/1500 to 1/10 of LD50 for mouse in all examined species showed no action suggesting teratogenic and embryotoxic properties. In contrary the development of fetuses of rats and hamsters (as indicated by body weight and length) was significantly better after all doses tested.

摘要

对（2S，2'S）-N，N'-二甲基-N，N'-双[1-（3'，4'，5'-三甲基苯甲酰氧基）丁基-2]乙二胺二盐酸盐（M-781，克拉维坦波尔法）在大鼠、金黄仓鼠和兔子身上进行了致畸和胚胎毒性活性研究。在所有受试物种中，口服剂量为3至450mg/kg，即小鼠半数致死量的1/1500至1/10，未显示出任何致畸和胚胎毒性作用。相反，在所有测试剂量后，大鼠和仓鼠胎儿的发育（以体重和体长表示）明显更好。