Lack of teratogenic and embryotoxic properties of (2S, 2'S) N,N'-dimethyl-N,N'-bis [1-(3', 4', 5'-trimethoxybenzoyloxy)-butyl-2] ethylenediamine dihydrochloride (M-71).

(2S,2'S) N,N'-dimethyl-N, N'-bis[1-(3', 4', 5'-trimethylbenzoyloxy-butyl-2] ethylenediamine dihydrochloride (M-781, Craviten Polfa) was examined for teratogenic and embryotoxic activities in rats, golden hamsters and rabbits. Doses ranging from 3 to 450 mg/kg po i.e. 1/1500 to 1/10 of LD50 for mouse in all examined species showed no action suggesting teratogenic and embryotoxic properties. In contrary the development of fetuses of rats and hamsters (as indicated by body weight and length) was significantly better after all doses tested.