Pharmacokinetic investigations of Craviten. II. Dose-dependent elimination kinetics in rats following rapid intravenous injection.

Serum and urine levels of iv administered Craviten were determined. Comparison of the decline of the same absolute and relative serum concentrations of the drug and the variation of pharmacokinetic parameters with the dose leads to the conclusion, that the elimination of Craviten in rats cannot be described by first-order kinetics. The amount of the drug found in urine indicates, that the fraction of Craviten eliminated in the intact form is about 1.27 per cent of the iv administered dose.