一种测定血红蛋白AI的快速微量色谱法。

A rapid microchromatographic method for determination of hemoglobin AI.

作者信息

Wålinder O

出版信息

Ups J Med Sci. 1980;85(2):151-8. doi: 10.3109/03009738009179182.

Abstract

Hemoglobin AI (HbAI) is a minor hemoglobin fraction, which is continuously formed by a glycosylation reaction throughout the life-span of the erythrocyte. The concentration of HbAI reflects the average blood glucose level during the preceding 1 - 2 months and HbAI-determinations have been found to be of value in long-term diabetes control. A simple and reliable microchromatographic method for HbAI-determinations, suitable for routine clinical analyses, is described. In a group of diabetic patients (n = 126) the mean (+ S.D.) S.D.) HbAI--value was 9.6 + 1.8%, in the reference group (n = 33) the corresponding value was 6.0 + 0.8%. A commercial kit (Bio-Rad) based on the same principle was compared with our method. It was of equal accuracy and gave comparable results.

摘要

血红蛋白AI（HbAI）是一种次要的血红蛋白组分，它在红细胞的整个生命周期中通过糖基化反应持续形成。HbAI的浓度反映了前1至2个月的平均血糖水平，并且已发现测定HbAI对长期糖尿病控制具有价值。本文描述了一种简单可靠的用于测定HbAI的微色谱法，适用于常规临床分析。在一组糖尿病患者（n = 126）中，HbAI的平均值（+标准差）为9.6 + 1.8%，在参考组（n = 33）中，相应的值为6.0 + 0.8%。将基于相同原理的商业试剂盒（伯乐公司）与我们的方法进行了比较。其准确性相同，结果具有可比性。