Morrison J A, Khoury P, Laskarzewski P, Gartside P, Moore M, Heiss G, Glueck C J
Trans Assoc Am Physicians. 1980;93:230-43.
This report was designed to describe and characterize the proportion of of hypercholesterolemic children and adults in the Lipid Research Clinics collaborative prevalence study whose elevated total plasma cholesterol levels were accounted for by elevated high density lipoprotein cholesterol (C-HDL), not by elevated levels of low density lipoprotein cholesterol (C-LDL). In randomly recalled 6-19 year old children having age-, race-, an sex-specific plasma cholesterol levels greater than or equal to 95th percentile levels, 22% of white males, 22% of white females, and 44% of black males had C-HDL, but not C-LDL greater than or equal to age-, sex-, and race-specific 95th percentile levels. In contrast, for adults (ages 20-79 years), 3% of white males, 10% of white females, 17% of black males, and 25% of black females had predominant hyperalphalipoproteinemia which accounted for their hypercholesterolemia. In participants defined as hypercholesterolemic on the basis of two examinations it was observed that the majority of children and adults were in the C-LDL elevated and C-HDL not elevated category. Hypercholesterolemic adults were not as likely as the hypercholesterolemic children to be in the C-HDL elevated and C-LDL not elevated category. For both children and adults, blacks were more likely to have predominant hyperalphalipoproteinemia accounting for their elevated total plasma cholesterol levels than were whites. For hyperalphalipoproteinemic, hypercholesterolemic children and adults, the mean ratio of C-LDL to C-HDL ranged from 1.3 to 1.4 (in children) and 1.4 to 2.1 (in adults), levels well below the overall mean ratio for the entire Lipid Research Clinics random recall group of 2.7 for children and 4.2 for adults. An understanding of the multiple etiologies of hyperalphalipoproteinemic-hypercholesterolemics may be useful in considering programs designed to elevate C-HDL over time, with an aim at reducing CHD risk.
本报告旨在描述和刻画脂质研究诊所协作患病率研究中高胆固醇血症儿童和成人的比例，这些人的血浆总胆固醇水平升高是由高密度脂蛋白胆固醇（C-HDL）升高所致，而非低密度脂蛋白胆固醇（C-LDL）水平升高。在随机召回的6至19岁儿童中，其年龄、种族和性别特异性血浆胆固醇水平大于或等于第95百分位数水平，22%的白人男性、22%的白人女性以及44%的黑人男性存在C-HDL升高但C-LDL未大于或等于年龄、性别和种族特异性第95百分位数水平的情况。相比之下，对于成年人（20至79岁），3%的白人男性、10%的白人女性、17%的黑人男性以及25%的黑人女性存在主要的高α脂蛋白血症，这导致了他们的高胆固醇血症。在基于两次检查被定义为高胆固醇血症的参与者中，观察到大多数儿童和成人属于C-LDL升高而C-HDL未升高的类别。高胆固醇血症成年人不像高胆固醇血症儿童那样容易属于C-HDL升高而C-LDL未升高的类别。对于儿童和成人而言，黑人比白人更有可能存在主要的高α脂蛋白血症，这导致其血浆总胆固醇水平升高。对于高α脂蛋白血症、高胆固醇血症的儿童和成人，C-LDL与C-HDL的平均比值在儿童中为1.3至1.4，在成人中为1.4至2.1，这些水平远低于脂质研究诊所随机召回组儿童的总体平均比值2.7和成人的4.2。了解高α脂蛋白血症性高胆固醇血症的多种病因，对于考虑旨在随着时间推移提高C-HDL以降低冠心病风险的项目可能是有用的。
