Tsang R C, Neely K, Glueck C J
Pediatr Res. 1981 Jan;15(1):66-9. doi: 10.1203/00006450-198101000-00016.
Interrelationships of high-density lipoprotein cholesterol (C-HDL) with total plasma cholesterol (TC), triglyceride, and low-density lipoprotein cholesterol, as well as longitudinal maintenance of C-HDL rank order (tracking) from birth to age 2 years were assessed in 76 hypercholesterolemic neonates (cord blood, TC greater than 95 mg/dl) with focus upon 34 hyperalphalipoproteinemic neonates who had cord blood C-HDL greater than 61 mg/dl, greater than or equal to the 99th percentile. Cord blood C-HDL correlated closely (P less than 0.01) with C-HDL at 6, 12, and 18 to 24 months (r = 0.32, 0.49, and 0.39, respectively). C-HDL levels at 12 months and 18 to 24 months were closely associated (r = 0.68 and P less than 0.01). C-HDL at birth, 6, and 12 months correlated positively (P less than 0.01) with TC levels (r = 0.28, 0.30, and 0.36, respectively). Conversely, C-HDL at birth, 6 and 12 months correlated inversely with TG (P less than 0.01) (r = -0.41, -0.40, and -0.49, respectively). At birth and at 18 to 24 months, C-HDL correlated inversely (P less than 0.05) with C-LDL (r = -0.36 and -0.31, respectively). Of neonates having cord blood C-HDL in the highest quartile, 38, 56, and 60%, respectively at ages 6, 12, and 18 to 24 months retained C-HDL levels in the highest quartile; 56, 75, and 70%, respectively, retained C-HDL levels greater than the 50th percentile. Of 13 neonates having the highest initial cord blood C-HDL levels, cord blood C-HDL greater than or equal to 69 mg/dl, nine had one or more C-HDL values greater than 70 mg/dl (the 90th percentile for childhood), throughout the 12- to 60-month follow-up period. Moreover, where more than one follow-up measurement was available, there was relative stability of elevated C-HDL measurements. Many infants with cord blood hyperalphalipoproteinemia are likely to have persistent elevations of C-HDL at ages 1 and 2 years. If they maintain elevated C-HDL into adulthood, they may, speculatively, be at reduced risk for coronary heart disease, given the strong inverse association of C-HDL with coronary heart disease.
在76名高胆固醇血症新生儿（脐血总胆固醇大于95mg/dl）中评估了高密度脂蛋白胆固醇（C-HDL）与总血浆胆固醇（TC）、甘油三酯和低密度脂蛋白胆固醇的相互关系，以及从出生到2岁C-HDL排名顺序的纵向维持情况（追踪），重点关注34名脐血C-HDL大于61mg/dl（大于或等于第99百分位数）的高α脂蛋白血症新生儿。脐血C-HDL与6、12以及18至24个月时的C-HDL密切相关（P<0.01）（r分别为0.32、0.49和0.39）。12个月以及18至24个月时的C-HDL水平密切相关（r = 0.68，P<0.01）。出生时、6个月和12个月时的C-HDL与TC水平呈正相关（P<0.01）（r分别为0.28、0.30和0.36）。相反，出生时、6个月和12个月时的C-HDL与甘油三酯呈负相关（P<0.01）（r分别为-0.41、-0.40和-0.49）。出生时以及18至24个月时，C-HDL与C-LDL呈负相关（P<0.05）（r分别为-0.36和-0.31）。脐血C-HDL处于最高四分位数的新生儿中，6岁、12岁以及18至24岁时分别有38%、56%和60%的人C-HDL水平仍处于最高四分位数；分别有56%、75%和70%的人C-HDL水平高于第50百分位数。在13名脐血C-HDL初始水平最高（脐血C-HDL大于或等于69mg/dl）的新生儿中，在12至60个月的随访期内，有9人的一个或多个C-HDL值大于70mg/dl（儿童期第90百分位数）。此外，在有多次随访测量数据的情况下，C-HDL测量值升高具有相对稳定性。许多脐血高α脂蛋白血症的婴儿在1岁和2岁时可能持续存在C-HDL升高的情况。鉴于C-HDL与冠心病之间存在强烈的负相关，如果他们成年后C-HDL仍保持升高，推测其患冠心病的风险可能会降低。
