Mikołajczyk H, Pach B
Acta Physiol Pol. 1981 Jan-Feb;32(1):63-72.
Adult male rats were individually accustomed to experimental conditions in 16X16X30 cm polymethacrylate chambers. Each of 12 rats was twice subjected during 5 hrs or 5 1/2 hrs to hypobarism at a simulated altitude of 3000 m (725 Hpa). The amounts of total glycosaminoglycans (GAG) and hydroxyproline (Hp) were determined in urine portions collected during the period of hypobaric exposure and during the remaining part of the day. Transient shock-like symptoms with high excitement and seizures occurred in 2 of 12 rats during reduction of air pressure for the first time and a significant augmentation of urinary GAG output was found in both rats during this hypobaric period. The remaining rats showed only slight dysbaric signs in the tympanic cavity during ascending to simulated altitude and return to environmental air pressure in the hypobaric chamber. These animals excreted lower amounts of GAG during the hypobaric periods and higher amounts of Hp during the next days after hypobarism.
成年雄性大鼠被分别安置在16×16×30厘米的聚甲基丙烯酸甲酯实验箱中，使其适应实验条件。12只大鼠中的每只在5小时或5个半小时内两次处于模拟海拔3000米（725百帕）的低气压环境中。在低气压暴露期间及当天剩余时间收集的尿液样本中，测定了总糖胺聚糖（GAG）和羟脯氨酸（Hp）的含量。在首次减压过程中，12只大鼠中有2只出现了短暂的类似休克症状，表现为高度兴奋和惊厥，且在这个低气压期间，这两只大鼠的尿GAG排出量均显著增加。其余大鼠在升至模拟海拔高度及返回低气压舱环境气压的过程中，仅在鼓室出现了轻微的气压性体征。这些动物在低气压期间排出的GAG量较低，而在低气压暴露后的接下来几天中排出的Hp量较高。
