Hutter J J, Sahn D J, Woolfenden J M, Carnahan Y
Am J Dis Child. 1981 Jul;135(7):653-7. doi: 10.1001/archpedi.1981.02130310057019.
Serial echocardiographic studies were performed on 48 children who received chemotherapy with doxorubicin hydrochloride (Adriamycin). For the group as a whole, no correlation could be made between the cumulative dose of doxorubicin administered and left ventricular systolic function as measured by the fractional shortening of the left ventricle (delta s). Two asymptomatic patients, however, demonstrated depressed delta s and abnormal results from radionuclide studies at cumulative doxorubicin doses of less than 430 mg/sq m. Differentiation of the echoderived curve of left ventricular minor axis dimension indicated that these two patients had abnormalities in both diastolic and systolic function. Good correlation was demonstrated between echocardiographic and radionuclide studies in eight patients, including the two with depressed function. Inherent variability limits the sensitivity of echocardiographic functional studies, but serial studies are helpful in the evaluation of cardiac function in children who receive doxorubicin.
对48名接受盐酸阿霉素（阿霉素）化疗的儿童进行了系列超声心动图研究。就整个组而言，所给予的阿霉素累积剂量与通过左心室缩短分数（δs）测量的左心室收缩功能之间没有相关性。然而，两名无症状患者在阿霉素累积剂量低于430mg/平方米时，δs降低，放射性核素研究结果异常。左心室短轴维度的超声心动图衍生曲线的差异表明，这两名患者的舒张功能和收缩功能均异常。包括两名功能降低的患者在内的8名患者的超声心动图和放射性核素研究之间显示出良好的相关性。内在变异性限制了超声心动图功能研究的敏感性，但系列研究有助于评估接受阿霉素治疗的儿童的心脏功能。
