Björkhem G, Garwicz S
Acta Paediatr Scand. 1977 Sep;66(5):595-600. doi: 10.1111/j.1651-2227.1977.tb07953.x.
Echocardiography was used to evaluate left ventricular function in 8 children treated with adriamycin for malignant disease. Preejection period (PEP), left ventricular ejection time (LVET) and percent change in left ventricular internal dimension with systole (delta LVID) were measured before, during and immediately after 22 injections of adriamycin as well as 14 injections of other cytotoxic drugs and physiologic saline. No immediate effects on left ventricular function could be discerned. When functional parameters were evaluated longitudinally in patients with relatively higher cumulative doses of adriamycin, percent change in left ventricular internal dimension with systole showed some tendency to decrease, while the other parameters remained essentially unchanged.
超声心动图用于评估8名因恶性疾病接受阿霉素治疗的儿童的左心室功能。在22次注射阿霉素期间及之后即刻，以及14次注射其他细胞毒性药物和生理盐水之前、期间及之后即刻，测量射血前期（PEP）、左心室射血时间（LVET）以及左心室内径在收缩期的变化百分比（ΔLVID）。未发现对左心室功能有即刻影响。在阿霉素累积剂量相对较高的患者中纵向评估功能参数时，左心室内径在收缩期的变化百分比有一定下降趋势，而其他参数基本保持不变。
