Grannikova S A, Rusakova E V, Budnitskaia P Z, Koroleva V M, Lorinskaia T M
Zh Mikrobiol Epidemiol Immunobiol. 1977 Oct(10):97-101.
A method of preparation of subtypical antisera to two determinants of hepatitis B surface antigen (anti-HBs Ag/ay and anti-HBs Ag/ad) is described. The test system obtained was approbated on 1400 antigen-positive sera collected from blood donors and patients suffering from acute and chronic virus hepatitis in various geographical zones of the USSR. HBs Ag/ay proved to prevail (84--100%), HBs Ag/ad was distributed irregularly--from 16% in the European part of the USSR to 0--4% in the republics of the Middle Asia and Siberian regions. HBs Ag/ad was mostly determined in the population of Western regions of the European part of the USSR (the Baltic republics, 43.4%, Moldavia 24.3%).
本文描述了一种制备针对乙型肝炎表面抗原两个决定簇的亚型抗血清（抗-HBs Ag/ay和抗-HBs Ag/ad）的方法。所获得的检测系统在从苏联不同地理区域的献血者以及患有急性和慢性病毒性肝炎的患者中采集的1400份抗原阳性血清上进行了验证。结果表明，HBs Ag/ay占主导（84%-100%），HBs Ag/ad分布不规律——在苏联欧洲部分为16%，在中亚各共和国和西伯利亚地区为0%-4%。HBs Ag/ad主要在苏联欧洲部分西部地区的人群中检测到（波罗的海各共和国为43.4%，摩尔多瓦为24.3%）。
