Perry E, Chaudhary R K
Can Med Assoc J. 1973 Nov 3;109(9):857-9.
Hepatitis B antigen (HBAg) from blood donors and patients with hepatitis was tested for ad and ay subspecificity by immunodiffusion in agarose. A total of 59 sera from blood donors and 81 sera from hepatitis patients were subtyped.Subtyping of HBAg from blood donors showed ad and ay subspecificity in 64.4 and 35.6% of cases respectively. Patients' sera on the other hand showed HBAg with ad and ay subspecificity in 6 and 94% of cases respectively. Therefore, ad subtype was more frequently associated with blood donors whereas ay subtype was predominant among hepatitis patients. The relationship between clinical findings and HBAg subtype is also discussed.
采用琼脂糖免疫扩散法对献血者和肝炎患者的乙肝抗原(HBAg)进行ad和ay亚特异性检测。共对59份献血者血清和81份肝炎患者血清进行了亚型鉴定。献血者HBAg的亚型鉴定结果显示,ad和ay亚特异性分别占64.4%和35.6%。另一方面,患者血清中HBAg的ad和ay亚特异性分别占6%和94%。因此,ad亚型与献血者的关联更为常见,而ay亚型在肝炎患者中占主导地位。文中还讨论了临床发现与HBAg亚型之间的关系。