Silvola H, Tourunen E, Mattila M J
Ann Clin Res. 1981 Feb;13(1):22-5.
20 patients who underwent thoracotomy and lung operations mainly for lung cancer, were given oral doxycycline (DC) 100-4-- mg the previous evening. Blood samples were taken for the fluorometric assay of DC before the anaesthetic, during the operation, and 2-3 hours postoperatively. Serum DC levels during the operation correlated approximately with the dose of DC, and they were parallel to the DC concentrations measured in pulmonary or/and bronchial tissue, 11 out of 20 patients showed elevated serum DC levels during recovery, non-specific fluorescence being excluded. This phenomenon was ot seen in experiments with rabbits in which the decline of the blood DC levels was assessed after the intravenous injection of DC. Possible causes for elevated serum DC are discussed.
20例主要因肺癌接受开胸肺手术的患者，于前一晚口服强力霉素（DC）100 - 4 - -毫克。在麻醉前、手术期间及术后2 - 3小时采集血样用于DC的荧光测定。手术期间血清DC水平大致与DC剂量相关，且与肺或/和支气管组织中测得的DC浓度平行。20例患者中有11例在恢复过程中血清DC水平升高，排除了非特异性荧光。在对兔静脉注射DC后评估血中DC水平下降的实验中未见到这种现象。文中讨论了血清DC升高的可能原因。
