Gnarpe H, Dornbusch K, Hägg O
Scand J Infect Dis Suppl. 1976(9):54-7.
As part of a longitudinal study, the influence of preoperative single dose doxycycline treatment on the overall incidence of early postoperative wound infections in orthopaedic surgery, 34 patients with various fractures were given an intravenous infusion of doxycycline 2-4 hours before the operation. The serum concentrations of doxycycline were determined on specimens taken during the operation and on 4 other occasions, the last being 48 hours after operation. All patients except 4 had serum concentration levels of 0.4 mug per ml or above at 48 hours. During the operation, specimens of skin, subcutaneous tissue, muscle and bone were also taken. The doxycycline concentrations were determined in the various tissues and correlated to the concomitant serum concentration. The results were analysed with regard to the possible influence of preoperative single dose doxycycline treatment for prevention of early postoperative infections.
作为一项纵向研究的一部分，为了探究术前单剂量强力霉素治疗对骨科手术术后早期伤口感染总体发生率的影响，34例不同骨折患者在手术前2 - 4小时接受了强力霉素静脉输注。在手术期间及另外4个时间点采集样本测定强力霉素的血清浓度，最后一次采样是在术后48小时。除4例患者外，所有患者在48小时时血清浓度水平均达到每毫升0.4微克或更高。手术期间，还采集了皮肤、皮下组织、肌肉和骨骼的样本。测定了不同组织中的强力霉素浓度，并将其与同期血清浓度进行关联。分析了术前单剂量强力霉素治疗对预防术后早期感染可能产生的影响。
