Thornsberry C, Barry A L, Jones R N, Baker C N, Badal R E, Packer R R
Antimicrob Agents Chemother. 1981 Jan;19(1):122-9. doi: 10.1128/AAC.19.1.122.
Fortimicin A, a pseudodisaccharide aminoglycoside, was found to have broad-spectrum activity against most clinically important aerobic and facultatively anaerobic bacteria, except Pseudomonas aeruginosa, some other Pseudomonas species, and streptococci. It was comparable to amikacin in its level of activity (minimum inhibitory concentrations) and spectrum of activity (except for the lack of activity on P. aeruginosa). Fortimicin A was bactericidal and was affected by cations when tested against P. aeruginosa. Minimum inhibitory concentrations were affected by the inoculum used in the susceptibility test. The drug was resistant to most aminoglycoside-inactivating enzymes, but probably is not active against permeability mutants.
福提霉素A是一种假二糖氨基糖苷类抗生素，已发现它对大多数临床上重要的需氧菌和兼性厌氧菌具有广谱活性，但对铜绿假单胞菌、其他一些假单胞菌属细菌以及链球菌除外。其活性水平（最低抑菌浓度）和活性谱与阿米卡星相当（除了对铜绿假单胞菌无活性）。福提霉素A具有杀菌作用，在针对铜绿假单胞菌进行测试时受阳离子影响。最低抑菌浓度受药敏试验中所用接种物的影响。该药物对大多数氨基糖苷类失活酶具有抗性，但可能对通透性突变体无活性。
